Sildenafil, the active substance of brand Viagra and its generics, is the medication is meant to treat erectile dysfunction (ED) of any origin (even antidepressant-induced sexual disorder) in men over 18 years old.
Sildenafil is cGMP(Cyclic guanosine monophosphate)-specific phosphodiesterase type 5 (PDE5) inhibitor. The cGMP enzyme controls penile blood flow, and Sildenafil causes degradation of PDE5. Put it simply, Sildenafil refines penile blood supply. No wonder that originally Sildenafil was used to treat cardiovascular diseases, including pulmonary arterial hypertension. In the course of numerous researches the medicine proved to cure sexual frustration – an inability to achieve or/and sustain satisfactory erection to perform a full intercourse.
Due to its effectiveness (95%), drugs with Sildenafil are the best-known and prioritized ED treatment not only in Australia, but round the whole world! The Byafront Company is happy to offer all ED sufferers the money-friendly generics containing FDA and Australian TGA-approved Sildenafil.
Breakthrough action of Sildenafil
Sildenafil prevents degradation of cGMP by PDE5 in the cavernous body of a male organ. Nitrogen oxide (NO) in penile cavernous bodies binds to receptors of guanylate cyclase, what leads to enhanced levels of cGMP, causing relaxation of smooth muscle (vasodilatation or expansion of blood vessels) of intimate cushions in penile helicine arteries.
This vasodilatation provokes stronger blood inflow into spongy tissues of the phallus, what results in rigidness of penis. In other words, Sildenafil acts like a selective inhibitor of PDE5, an enzyme responsible for degradation of cyclic guanosine monophosphate in penile cavernous bodies.Without natural sexual excitement Sildenafil does not cause erection as we have just determined that erection is generated by activation of the NO/cGMP system.
By the way, Sildenafil is not only used by ED sufferers, but by professional sportsmen as well since the medication expands blood vessels, it helps athletes to achieve muscle definition and increase endurance during trainings and improve recovery after hard exercises.
Notably that Sildenafil based medications are popular even with those men who are not diagnosed with erectile dysfunction. As the active agent boosts blood flow into the male organ, it increases sensibility (libido), prolongs sexual performance and sharpens orgasm. That is why Sildenafil is good for recreational use too but at a reduced dose of 50 mg.
Sildenafil description
Sildenafil is available in the form of 25, 50, 100 mg film-coated, diamond-shaped tablets of white to off-white color. Generics, containing this agent, are also produced in the form of soft tablets, sachets, capsules or oral jellies with various flavors. The variety of forms is accounted for that the manufacturers strive to outperform their pharmaceutical competitors and provide customers with the most convenient and fast-acting form of Sildenafil.
How Sildenafil must be taken
The recommended dose of Sildenafil is 50 mg within 24 hours. The dose is taken an hour before sexual intercourse. Depending on tolerability and effectiveness, the dosage can be increased up to 100 mg (the maximum dose) or decreased up to 25 mg.
Though the medication is rapidly absorbed (max concentration in plasma is observed in 20-120 minutes after taking), fat meal and alcohol delay activity of Sildenafil. In absence of specific health conditions, dosage adjustments are not necessary for elderly (over 65 years old) men. Still there are some pathologies under which Sildenafil dose is reduced to 25 mg:
- Renal impairment;
- Hepatic impairment;
- Severe Cardiovascular conditions;
- Anatomical deformation of the penis.
What side effects can Sildenafil cause?
If a man has no contradictions and does not exceed the recommended dose, side effects caused by Sildenafil are uncommon. Among them are:
- Dizziness and headache;
- Flushing and hot flush;
- Nausea;
- Visual disturbance;
- Tachycardia or hypertension.
Since Sildenafil potentiates the hypotensive effect of organic nitrates, the patients who take nitric oxide donors must not combine their treatment with Sildenafil based drugs.
Super action of Sildenafil
The drug works perfectly in 95% of cases and truly changes people’s lives for better. You know, quality sex plays a crucially important part in a man’s life. Sex is the only natural way to save health of males and females: it actively helps people burn calories, promotes heart health, improves sleep, stifles stress, enforces immune system, makes people look 10 years younger, promotes wounds healing, and even prevents cancer! Without frequent sex (2-3 times a week) men put their health in real danger!
Unfortunately, due to physiological, psychic or both reasons men cannot perform a satisfactory sexual intercourse what badly affects their mental and physical health. Life quality gets seriously spoiled what results in nervous breakdowns, inferiority complex, difficult interpersonal relationships, aggressive behavior and even development of suicidal tendencies.
For centuries there have not been effective treatments for erectile dysfunction, until Sildenafil was invented less than 20 years ago. Since then sexual frustration and impotency have become successfully curable. ED treatment is not the only life-saving benefit of Sildenafil. There are many others like:
- lung conditions. Sildenafil is prescribed for men suffering from pulmonary arterial hypertension (PAH). This ailment is featured with high blood pressure in lung arteries. The medication makes lungs blood vessels relax what prevents constriction and hypoxia.
- Congestive heart failure. Sildenafil decreases heart rate and blood pressure during sex what makes sexual activity of these patients absolutely safe. Sildenafil is given to prematurely born children to cure their heart or lung problems.
- 75% of diabetics experience delayed stomach emptying. Sildenafil is proven to relax stomach muscles what keeps insulin and blood sugar level stabile.
- Prostate cancer. In combination with doxorubicin Sildenafil has an evident antitumor effect, while reducing the negative impact of the former on the heart.
- Sildenafil quickens recovery from jet lag. The cGMP controls the sleep-wake cycle too by releasing hormones and neurotransmitters. Sildenafil promotes the effect of the enzyme by protecting it from degradation by PDE5. So that the body gets more adoptable for time switches.
- Heart stroke. Sildenafil helps regain basic functions (movement, language and thinking) after stroke. Our favorite cGMP turned out to generate new brain cell too! And we have already known what effect Sildenafil has on this enzyme.
